greedy b.......

[coach et 64]

It has come to Coachie's attention that some Essex clubs are reticent in releasing players for the County youth rep sides.I would like to remind to some of these clubs that playing for the County is an honour and shouldn't prevent these talented players from being called up.It is a chance for these youngsters to put themselves on the shop window out there with a lot of league scouts attending the games..Essex County FA hasn't won a trophy since Stanley Matthews days but i'm not surprised because they are prevented from putting out the best side that represents thruthfully the quality of youth football in our County.A lot of the other Counties adopt a tougher approach and if the club refuse to release the player,they ban him from playing for his club that week.In doing so they can call up the best youth players available and clearly have an advantadge over our Essex rep side.How some clubs can act like this is beyond me!In most cases is only one or maximum 2 players and i refuse to think that one player is so important for his side!gredy f...

[Beachboys]

ZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZ

[coach et 64]

wait till the FA flex the muscles...

[Talk_Is_Cheap]

What they gonna put a boring ban on you coachie..?

[coach et 64]

they will do what other Counties Fa do...ban the player from playing for that club on that date.Elementary Baldy,pardon De La pena-Lombardo

[Uncle Urchin]

coachey is the new medical alternative for mogodon...

[coach et 64]

What is Mogodon?

[coach et 64]

Originally Posted By: Uncle Urchin

coachey is the new medical alternative for mogodon...

View Full Version : Pharmacology - Nitrazepam (Mogodon)


--------------------------------------------------------------------------------

Jatelka08-25-2007, 06:24 AM
Nitrazepam is 9-nitro-6-phenyl-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one.

It has the chemical formula C (http://en.wikipedia.org/wiki/Carbon)15H (http://en.wikipedia.org/wiki/Hydrogen)11N (http://en.wikipedia.org/wiki/Nitrogen)3, and a molecular weight of 281.3.

http://www.drugs-forum.co.uk/photopost/data/533/Nitrazepamstructure.jpg

It is a yellow crystalline powder which is insoluble in water, and soluble in alcohol, ether and chloroform. It has a melting point of 226-229 C.

Pharmacokinetics

It is well and fairly rapidly absorbed from the GI tract, when taken orally. Peak plasma concentrations occur at 2 hours (0.5 – 5 hours). Peak plasma levels following an oral dose of 10mg are 68-108ng/ml. 12 hours after oral administration levels are 12 – 38 ng/ml.

Bioavailability varies from 54% (oral) to 94% (iv). It is 87% protein bound.

It is metabolised I the liver to 7-aminonitrazepam and then to 7-acetamidonitrazepam, and is then hydroxylated. The metabolites are not thought to have significant pharmacological activity. Nitrazepam does not cause liver enzyme induction or inhibition with long term treatment.

Clearance is 4.1+/- 2 L/ hour , and 4.7 +/- 1.5 L/hour in the over 65’s.

It is mainly excreted as urinary metabolites, aprox 70% of a dose is excreted this way. Less than 1% is excreted unchanged.

Half life is 16-48 hours (mean 27).

From clinical studies: Nitrazepam is absorbed at variable rates, and there is a lot of inter-individual variation in peak plasma levels. It crosses the blood brain barrier, and is excreted in breast-milk.

Indications

It is licensed for use in (the short-term) the treatment of insomnia. Usual therapeutic dose is 5-10mg at night.

Contraindications

Hypersensitivity, Chronic/Severe respiratory disease, severe hepatic impairment. Caution is advised in renal impairment.

Interactions

There is an additive sedative effect with other CNS depressants (including alcohol). Because Nitrazepam undergoes oxidative metabolism drugs which reduce this (such as cimetidine and disulfiram) increase plasma levels. The anti-cholinergic effects of drugs such as antihistamines and some antidepressants are potentiated by Nitrazepam. Niytrazepam also interacts with some anticonvulsants.

Adverse effects

Anterograde amnesia (including complex behaviours such as sleep-driving and sleep-sex) have been reported. This can occur with normal therapeutic doses, and is more likely when the maximum dose is exceeded, or when it is combined with other CNS depressants. Somnolence and dizziness are common.

There have been rare reports of angioedema and anaphylaxis.

As with all benzodiazepines, physical dependence and withdrawal can occur with as little as 14 days continuous use. Nitrazepam should not be discontinued abruptly.

Other rare side effects include low blood counts and deranged liver function tests. Periodic blood monitoring is advised.

Nitrazepam (and other benzodiazepines) may increase depression, and are not recommended as first line treatment. They can also worsen confusion and psychotic symptoms in schizophrenia and mania. Suicidal tendencies may be unmasked.

Paradoxical reactions (agitation, hallucination and aggression) may occur.

Use in Pregnancy

Is not recommended, and neonatal withdrawal symptoms have been reported. Foetal abnormalities have been demonstrated in studies with other benzodiazepines in the first trimester. Nitrazepam is excreted in breast milk, and should not be used by nursing mothers.

Knowledge is the bomb!

[cider]

Could it be that players get tapped up by the managers or coaches of the rep side.I know this has happened in the past once or twice.

[Uncle Urchin]

fck me coachies found google and wikepedia...now we are in serious trouble...

[Bitch]

[coach et 64]

Originally Posted By: Uncle Urchin

fck me coachies found google and wikepedia...now we are in serious trouble...

no worry me old friend...i'm a pacific character

[Hookey]

Post your result at APSA postie Coach, or was it off?